| Substitute (Name Used in the Federal Register) | ODS Being Replaced | End-uses | Reason |
| All flammable refrigerants, including OZ-12 (Hydrocarbon Blend A), HC-12a (Hydrocarbon Blend B), and Duracool 12a | CFC-12 | Motor vehicle air conditioning, retrofit and new | Lack of adequate assessment that characterizes incremental flammability risk |
| OZ-12 (Hydrocarbon Blend A), HC-12a (Hydrocarbon Blend B), and Duracool 12a | CFC-12 | All end-uses other than industrial process refrigeration, retrofit and new | Lack of adequate assessment that characterizes incremental flammability risk |
| R-141b | CFC-11 | centrifugal chillers, new | High ODP; other substitutes with lower overall risk have been identified |
R-176
(R-176 contains CFC-12, HCFC-22, and HCFC-142b. It is a different product from RB-276, typically sold under the name "Free Zone.") | CFC-12 | All end-uses, retrofit and new | Contains CFC-12 |
| R-403B | R-502 | All end-uses, retrofit and new | Contains a perfluorocarbon that exhibits extremely high GWP and very long lifetime |
| R-405A | CFC-12 | All end-uses, retrofit and new | Contains a perfluorocarbon that exhibits extremely high GWP and very long lifetime |
| MT-31 | all CFCs and HCFCs | All end-uses, retrofit and new | Toxicity of a constituent |
| Hexafluropropylene (HFP) and blends containing it | all CFCs and HCFCs | All end-uses, retrofit and new | HFP is toxic |
| NARM-22 | HCFC-22 | All end-uses, retrofit and new | Contains HCFC-22 |
| Self-Chilling Cans using HFC-134a or HFC-152a | CFC-12, HCFC-22, R-502 | Household Refrigeration, Transport Refrigeration, Vending Machines, Cold Storage Warehouses and Retail Food Refrigeration; retrofit and new | Unacceptably high greenhouse gas emissions from direct release of refrigerant to the atmosphere |
